Article type: Letter to Editor
Article
title: Acute phenytoin toxicity: an overview
Journal: Annals
of Indian Psychiatry
Year: 2020
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari
Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Phenytoin (PHT) is an antiepileptic drug with a narrow therapeutic index and large interpatient metabolism variability that is still widely used in underdeveloped countries. The probable main mechanism of action is a membrane sodium channel blockage that is voltage-dependent, which obstructs the positive feedback that underlies the development of seizure activity. However, other mechanisms may contribute to this drug's efficacy too. Herewith, we would like to address some important topics that, together with the study of Lucca et al., could lead to a better comprehension of PHT toxicity.
Keywords: Phenytoin, anticonvulsant, toxicity, intoxication, dilantin
Full text
available at:
DOI
10.4103/aip.aip_69_19
Citation
Rissardo JP, Caprara AL. Acute phenytoin toxicity: an overview. Ann Indian Psychiatry
2020;4:104