Article type: Review Article
Article
title: Bupropion-associated
movement disorders: a systematic review
Journal: Annals
of Movement Disorders
Year: 2020
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari
Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Bupropion
(BPP) was originally an antidepressant, but now it is also used for seasonal
affective disorder and smoking cessation. The aim of this systematic review was
to evaluate the clinical epidemiological profile, pathological mechanisms, and
management of BPP-associated movement disorders. Relevant reports in six
databases were identified and assessed by two reviewers without language
restriction. A total of 63 reports of 710 cases from 16 countries were
assessed. The movement disorders associated with BPP found clearly defined
were: dyskinesia (8), dystonia (7), parkinsonism (7), myoclonus (6), tic (6),
stuttering (3), rapid eye movement sleep disorders (2), and ballism (1); the
not clearly defined cases included 488 tremors, 80 slurred speech, 48 ataxia,
20 abnormal movements, 19 falls, 4 akathisia, 3 dyskinesia, 2 hyperkinesia, 2
poor coordination, and the rest was only reported once (dystonia, myoclonus,
motor tic, and rigidity). The mean age was 46 years (7–85 years). The male was
predominant sex (52.77%). The mean BPP dose was 248.38 mg, and the most common
indication was a major depressive disorder (73.68%). The average time of onset
was 3.47 weeks and of recovery was 2.71 weeks. The most common management was
BPP withdrawal. In the literature, the majority of the cases did not clearly
report the clinical neurological examination and lacked electrodiagnostic
studies. Future studies about adverse effects with BPP should describe at least
the clinical characteristics and the physical exam of the individuals,
especially when fall and slurred speech are observed.
Keywords: Amfebutamone, bupropion, drug-induced, movement
disorder, systematic review
Full text available at:
DOI
10.4103/AOMD.AOMD_35_19
Citation
Rissardo JP, Caprara AL. Bupropion-associated movement disorders: a systematic review. Ann Mov Disord 2020;3:86-98
