Article type: Letter to Editor
Article
title: Head-and-neck
paragangliomas
Journal: Formosan
Journal of Surgery
Year: 2020
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari
Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
A systematic review of the genetic analysis of paragangliomas from the head and neck showed that 10 out of 15 genes only when mutated can turn the individual susceptible to the development of these tumors. In this way, they discussed the influence of the main genetic drivers on the somatic molecular phenotype shown by DNA methylation and microRNA profiling. They stated that assuming a case of sporadic without doing a careful clinical observation could lead to a high number of misdiagnoses. Some of the genetic mutations associated with paragangliomas can skip generations or have variable penetrance, so in every case where these tumors have encountered a pedigree, a description should be done.
Key-words: paragangliomas lymph node, biopsy
Full text available at:
DOI
10.4103/fjs.fjs_105_19
Citation
Rissardo
JP, Caprara AL. Head-and-neck paragangliomas. Formos J Surg 2020;53:121-2
