Article title: A pathophysiological mechanism for valproate-induced hyperammonemia
Journal: Journal of Nature and Science of Medicine
Year: 2023
Authors: Jamir Pitton Rissardo, Ana LetÃcia Fornari Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
VPA is one of the most frequently used anticonvulsant drugs. Furthermore, it is approved for managing migraine and bipolar mania due to its broad spectrum. The mechanism of this medication is not clearly understood, but it probably involves an increased level of the inhibitory neurotransmitter gamma-aminobutyric acid. In this context, VPA is associated with multiple adverse events, such as influences in metabolic pathways causing hyperammonemia. Herein, we would like to discuss the mechanism of VPA-associated hyperammonemia.
Keywords: Valproic acid, valproate, ammonia, hyperammonemia, encephalopathy
Full text available at:
https://www.jnsmonline.org/article.asp?issn=2589-627X;year=2023;volume=6;issue=1;spage=1;epage=2;aulast=Rissardo
DOI
10.4103/jnsm.jnsm_19_22
Citation
Rissardo JP, Fornari Caprara AL. A pathophysiological mechanism for valproate-induced hyperammonemia. J Nat Sci Med 2023;6:1-2