138. A pathophysiological mechanism for valproate-induced hyperammonemia

Article type: Letter to Editor

Article title: A pathophysiological mechanism for valproate-induced hyperammonemia

Journal: Journal of Nature and Science of Medicine

Year: 2023

Authors: Jamir Pitton Rissardo, Ana Letícia Fornari Caprara

E-mail: jamirrissardo@gmail.com


ABSTRACT

VPA is one of the most frequently used anticonvulsant drugs. Furthermore, it is approved for managing migraine and bipolar mania due to its broad spectrum. The mechanism of this medication is not clearly understood, but it probably involves an increased level of the inhibitory neurotransmitter gamma-aminobutyric acid. In this context, VPA is associated with multiple adverse events, such as influences in metabolic pathways causing hyperammonemia. Herein, we would like to discuss the mechanism of VPA-associated hyperammonemia. 

Keywords: Valproic acid, valproate, ammonia, hyperammonemia, encephalopathy


Full text available at:

https://www.jnsmonline.org/article.asp?issn=2589-627X;year=2023;volume=6;issue=1;spage=1;epage=2;aulast=Rissardo


DOI

10.4103/jnsm.jnsm_19_22


Citation

Rissardo JP, Fornari Caprara AL. A pathophysiological mechanism for valproate-induced hyperammonemia. J Nat Sci Med 2023;6:1-2