NeuroTeach 25 - Nystagmus Part IV (Upbeat nystagmus)

Nystagmus series – Part IV

(upbeat nystagmus)

“Bruns ataxia, Bruns syndrome, Bruns law, Bruns nystagmus”

German neurologist Ludwig Bruns (1858–1916)


2)
Pathophysiology
“lesions from medulla to midbrain” Caudal medulla -nucleus intercalatus; nucleus of roller; nucleus of paraphales Midbrain -ventral tegmental tract (connection between vestibular nuclei & semicircular canals) Rostral pons & medullar -brachium conjunctivum


3) Fixation in central vestibular nystagmus
“poorly suppressed by fixation of a visual target” - abnormal smooth-pursuit system


4)
Making upbeat nystagmus more noticeable
Alexander’s law - looking up Bedside maneuvers - change head position


5) Obs
a) slow-phase without specific waveform b) convergence does not specific change nystagmus c) sometimes increased by looking down - slow-phase shows increasing velocity d) different - gaze-holding failure: myasthenia gravis - mixed upbeat-torsional: BPPV – posterior canal

6) Bow-tie nystagmus
abnormal: - vertical vestibular - smooth-pursuit responses - saccadic intrusions (square-wave jerks) marked saccadic hypermetria


7)
Upbeat nystagmus – features i) evoked by looking up ii) no suppress by visual fixation

8)
Upbeat nystagmus

9) Upbeat nystagmus

- bowtie nystagmus


10) Upbeat nystagmus

- sometimes increased by looking down (slow-phase shows increasing velocity)


11) Upbeat nystagmus


12) Upbeat nystagmus


13) Upbeat nystagmus


14) Upbeat nystagmus


15) Upbeat nystagmus


16) Upbeat nystagmus


17) Upbeat nystagmus

- sometimes increased by looking down (slow-phase shows increasing velocity)