Article type: Letter to the Editor
Article title: Neuroprotective Effect of Metformin
Journal: Ibnosina Journal of Medicine and Biomedical Sciences
Year: 2023
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Metformin is a biguanide antihyperglycemic agent known for its ability to reduce glucose production and improve insulin sensitivity. In 1922, Emil Werner and James Bell first described metformin as an N,N-dimethylguanidine product. However, there are some side effects associated with metformin. Recent studies have shown that this biguanide agent can mediate neuroprotection. Herein, we would like to discuss the current literature regarding the neuroprotective effects of metformin.
Keywords: Neuroprotection, metformin, microglia, stroke, neurodegenerative.
Full text available at:
DOI
10.1055/s-0043-1770928
Citation
Rissardo JP, Caprara AL. Neuroprotective Effect of Metformin. Ibnosina J Med Biomed Sci 2023;15:148-149. https://doi.org/10.1055/s-0043-1770928
Figure 1. Neuroprotective effect of metformin. AMPK, adenosine monophosphate-activated protein kinase; BDNF, brain-derived neurotrophic factor; DNA, deoxyribonucleic acid; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; PP2A, protein phosphatase 2A; ROS, reactive oxygen species.