Article type: Letter to the Editor
Article title: Neurological Manifestations of Snakebite Envenoming
Journal: Medical Journal of Dr. D.Y. Patil Vidyapeeth
Year: 2024
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Snakebite envenomation is a neglected tropical disease and is a significant public health burden in the developing world. About five million people worldwide are bitten by snakes every year, resulting in more than two million cases of envenomation. The venom of many elapids and some viperid snakes contains neurotoxins that induce descending flaccid neuromuscular paralysis. α-neurotoxins, β-neurotoxins, dendrotoxins, and fasciculins are the main neurotoxins found in snake venoms. Also, there are the three-finger toxins that form an abundant family of nonenzymatic proteins found in snake venoms, which are characteristically identified by their spatial structure, in which three loops (fingers) protrude from the central core, stabilized by four conserved disulfide bonds. The different neurotoxins are found in various percentages among other snake families. Herein, we would like to discuss the neurological manifestation of snakebite envenomation. The most common neurological presentations of snakebites are cerebrovascular events and neuromuscular paralysis.
Keywords: Hemotoxin, neurotoxin, neglected disease, cerebrovascular, neuromuscular.
Full text available at:
DOI
10.4103/mjdrdypu.mjdrdypu_382_23
Citation
Rissardo JP, Caprara AL. Neurological manifestations of snakebite envenoming. Med J DY Patil Vidyapeeth 2024;17:905-6.
