Article type: Case Report and Literature Review
Article title: Pregabalin-Induced Parkinsonism: Case Report and Review of the Literature
Journal: Journal of Pharmacy Practice
Year: 2024
Authors: Hossam Tharwat Ali, Sara Abdelhameed Khalil, Ana Leticia Fornari Caprara, Jamir Pitton Rissardo,
E-mail: jamirrissardo@gmail.com
ABSTRACT
Pregabalin is an anti-epileptic drug approved for the treatment of neuropathic pain and focal-onset seizures. In a few cases, pregabalin was associated with parkinsonism. We present a case of a 48-year-old female who had hypertension and was on losartan 50 mg/daily. Her general practitioner prescribed pregabalin 150 mg/daily for fibromyalgia-related pain. The subject doubled the dosage without medical advice. After 5 days of the increased dosage, she started to experience difficulty and slowness in movement associated with resting tremors. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable. Secondary parkinsonism was suspected, so pregabalin was discontinued. The subject fully recovered within 7 days. To the authors’ knowledge, only 6 cases of pregabalin-induced parkinsonism were reported in the literature. Pregabalin discontinuation was the most common management. All individuals fully recovered after pregabalin withdrawal. The mechanism of pregabalin-induced parkinsonism is not fully understood.
Keywords: pregabalin; parkinsonism; gabapentin; parkinson’s; drug-induced.
Full text available at:
DOI
10.1177/08971900241247119
Citation
Ali HT, Khalil SA, Caprara ALF, Rissardo JP. Pregabalin-Induced Parkinsonism: Case Report and Review of the Literature. J Pharm Pract 2024;37:1220-1224.
Figure 1. Mechanism of action of pregabalin.
Table 1. Reported Cases of Pregabalin-Induced Parkinsonism.