Stroke - ICAD
Etiology
- hypoperfusion
- artery-artery occlusion
- branch artery disease (BAD)
- hypoperfusion
- artery-artery occlusion
- branch artery disease (BAD)
Observations
- MC east Asian; 2nd Brazil
- recurrence of stroke in ICAD is around 30% in one year
- asymptomatic ICAD vs no ICAD has the same stroke risk
- MC east Asian; 2nd Brazil
- recurrence of stroke in ICAD is around 30% in one year
- asymptomatic ICAD vs no ICAD has the same stroke risk
Blood pressure trials
WASID
- BP > 160/90 inc risk TIA/stroke
SAMMPRIS
- BP > 140/90 inc risk TIA/stroke
Management trials
*BMM - best medical management
WASID
- warfarin vs ASA, no difference
SAMMPRIS
- BMM is supererior to stenting
CASSISS
- BMM is the same as stenting 3 wks after stroke
BASIS
- balloon angioplasty leads to restenosis frequently
PRINCE
- ticagrelor & ASA vs clopidogrel & ASA
> ticagrelor group had lower bleeding risk
CHANCE 2
- ticagrelor & ASA vs clopidogrel & ASA
> ticagrelor group is more effective
COMPASS
- rivaroxaban w/ or w/o ASA, no difference
CAPTIVA
- clopidogrel & ASA vs ticagrelor & ASA vs rivaroxaban & ASA
- being studied