RLS

Restless legs syndrome


- Start w/ gabapentin enacarbil (Horizant) > gabapentin > pregabalin

- IV iron: ferric carboxymaltose >  low molecular weight iron dextran > ferumoxytol > ferrous sulfate
> IV iron sucrose (ferritin <200 and saturation <20%)
*Appropriate iron status: Ferritin <= 75, transferrin saturation <20% plus ferritin 75-100. 

- Others: dipyridamole, extended-release oxycodone

- Devices: Nidra (bl high-frequency peroneal nerve stimulation)

- Against: levodopa, pramipexole, transdermal rotigotine, bupropion, carbamazepine, clonazepam, valerian, valproic acid, cabergoline

> if needs a dopamine agonist, consider Neupro (transdermal rotigotine)
- special situations: 
> ESRD: Vit C
> PLMD: against triazolam, VPA