Authors: Justin Chen, Muhammad Hassan Waseem, Zain ul Abideen, Jamir Pitton Rissardo, Brandon Lucke-Wold, Sania Aimen
Conference: 2025 AANS Annual Meeting, Boston, MA
Introduction
Metastatic brain tumors are a significant cause of mortality among older adults in the United States, with trends influenced by demographic and geographic factors. This study examines mortality patterns related to metastatic brain tumors in adults aged 55 and older from 1999 to 2020.
Methods
We extracted and analyzed the death certificate data from the CDC WONDER database using the Multiple-cause of death MCD-ICD 10 code (C79.3) in older adults (≥55). Crude death rates and age-adjusted mortality rate (AAMR) per 100,000 were calculated. Annual percentage changes (APCs) along with 95% CI were analyzed using the Joinpoint regression program and stratified by age, year, gender, race, state, and census region.
Results
There were 301,862 metastatic brain tumor-related deaths in older adults in the US from 1999-2020. There was a significant decline in overall mortality from 1999 to 2007 (APC= -4.41, 95% CI:[-4.83, -3.98]), from 2007 to 2013 there was a slight decline (APC= -0.58, 95% Ci: [-1.44, 0.27]), this was followed by a steep incline from 2013 to 2017 (APC=3.96, 95% CI:[2.72, 5.21]), thereafter the trends remained relatively stable till 2020. Men had a consistently higher AAMR than women from 1999 (AAMR men: 28.7 vs. women: 20.8) to 2020 (AAMR men: 20.9 vs women: 17.8). On geospatial analysis Arkansas demonstrated the highest state-level AAMR (35.6), while Utah had the lowest (11.0). The Midwest showed the highest AAMR among the census regions (19.6). Most metastatic brain tumor-related deaths occurred at home (41.6%).
Conclusion
Metastatic brain tumor-related mortality in older adults showed an initial decline followed by an increase from 2013 to 2017, with men, the Midwest region, and Arkansas exhibiting the highest mortality rates, and most deaths occurring at home.
Citation
Chen J, Waseem MH, Abideen Z, Rissardo JP, Lucke-Wold B, Aimen S. Racial and Geospatial Variations in Metastatic Brain Tumor Related Mortality in Older Adults in the United States (1999-2020): An Insight from the CDC WONDER database. J Neurosurg 2025. https://aans2025.eventscribe.net/fsPopup.asp?PosterID=723772&mode=posterInfo