Infantile spasms

Infantile spasms

Definition
IS is time diagnosis
- Btw 3 to 18 months, peak 6 months
- 50% remission by age 3yo, 90% by age of 5yo

Important
↑risk TSC1&2 and down syndrome

Differentials
<3mo→ Ohtahara vs Sandifer
Evaluation
Prompt EEG and treatment delay→ assoc w/ worsens neurodevelopmental outcomes