Article type: Review Article
Article
title: Pregabalin-associated
movement disorders: a literature review
Journal: Brain
Circulation
Year: 2020
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari
Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Central
nervous system adverse effects are commonly reported with pregabalin (PGB). On
the other hand, movement disorders (MDs) associated with this drug were rarely
described. However, their occurrence could significantly affect the quality of
life of PGB users. This literature review aims to evaluate the clinical
epidemiological profile, pathological mechanisms, and management of
PGB-associated MDs. Relevant reports in six databases were identified and
assessed by two reviewers without language restriction. A total of 46 reports
containing 305 cases from 17 countries were assessed. The MDs encountered were
as follows: 184 individuals with ataxia, 61 with tremors, 39 with myoclonus, 8
with parkinsonism, 1 with restless legs syndrome, 1 with dystonia, 1 with
dyskinesia, and 1 with akathisia. The mean age was 62 years (range: 23–94). The
male sex was slightly predominant with 54.34%. The mean PGB dose when the MD
occurred was 238 mg, and neuropathic pain was the most common indication of
PGB. The time from PGB start to MD was < 1 month at 75%. The time from PGB
withdrawal to recovery was < 1 week at 77%. All the individuals where the
follow-up was reported had a full recovery. The most common management was PGB
withdrawal. In the literature, the majority of the cases did not report
information about timeline events, neurological examination details, or
electrodiagnostic studies. The best management for all MDs is probably PGB
withdrawal. If the patient is on dialysis program, perhaps an increased number
of sessions will decrease recovery time. Furthermore, the addition of a
benzodiazepine could accelerate recovery.
Keywords: Ci-1008, drug-induced, literature
review, movement disorder, pregabalin
Full text available at:
DOI
10.4103/bc.bc_57_19
Citation
Rissardo JP, Caprara AL. Pregabalin-associated
movement disorders: a literature review. Brain Circ 2020;6:96-106
