Article type: Review Article
Article
title: Lamotrigine-associated
movement disorder: a literature review
Journal: Neurology
India
Year: 2021
Authors: Jamir
Pitton Rissardo, Ana Letícia Fornari Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Background: Lamotrigine (LMT) is a phenyltriazine
derivative that was originally described as an antiepileptic drug. Objective:
This literature review aims to evaluate the clinical epidemiological profile,
pathological mechanisms, and management of lamotrigine-associated movement
disorders. Methods: Relevant reports in six databases were identified and
assessed by two reviewers without language restriction. Reports that the
individuals only developed tremor or ataxia after LMT use were not included. Results:
In total 48 reports of 108 cases from 19 countries were assessed. The movement
disorders associated with LMT found were 29 tics, 21 dyskinesias, 14 myoclonus,
13 parkinsonism, 10 dystonia, and 1 stuttering. The not clearly defined cases
included 10 akathisia, 4 myoclonus, 4 cerebellar syndromes, 1 hypertonia, 1
dyskinesia, and an unknown number of dystonia cases. The mean reported age was
33.34 years (range: 1.574 years). The male was the predominant sex and the most
common LMT indication was epilepsy. The mean LMT-dose at the movement disorder
onset was 228 mg. The time from LMT start to the onset of movement disorder was
within 6 months in 81%. The time from LMT withdrawal to complete recovery was
within 1 month in 83%. The most common management was LMT withdrawal. Conclusions:
In the literature, the majority of the cases did not give a clear picture of
the individual, and the times of movement disorder onset and recovery are not
described. We believe that before withdrawal LMT, a dose adjustment based on
the benefits and adverse events with careful evaluation case-by-case can be
done.
Keywords: Bw430c, drug-induced,
lamotrigine, movement disorder, review
Full text available at:
https://pubmed.ncbi.nlm.nih.gov/34979637/
DOI
10.4103/0028-3886.333440
Citation
Rissardo JP, Caprara AL. Lamotrigine-associated movement disorder: a literature review. Neurol India 2021;69:1524-38
