Article type: Letter to Editor
Article
title: Phenytoin
psychosis
Journal: Apollo
Medicine
Year: 2020
Authors: Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
PHT is an antiepileptic drug, which is still widely
used in developing countries. It has narrow therapeutic index and large
interpatient metabolism variability. The main mechanism of action of this drug
involves the block of membrane sodium channels that are voltage dependent.
However, other possible mechanisms may also contribute to this drug's efficacy.
Here, we would like to discuss some important topics that together with the
study of Dahiya et al. could lead to a better comprehension of acute PHT
toxicity.
Keywords: Acute psychosis, adverse drug
reaction, antiepileptic drug-induced psychotic disorder, antiepileptic drugs,
de-challenge, phenytoin
Full text available at:
DOI
10.4103/am.am_62_19
Citation
Rissardo
JP, Caprara AL. Phenytoin psychosis. Apollo Med 2020;17:295-6
