Article type: Letter to Editor
Article title: Comprehensive idiopathic normal-pressure hydrocephalus theory: pathophysiological mechanism
Journal: Menoufia Medical Journal
Year: 2023
Authors: Jamir Pitton Rissardo, Ana LetÃcia Fornari Caprara
E-mail: jamirrissardo@gmail.com
ABSTRACT
Idiopathic normal-pressure hydrocephalus (NPH) is an intriguing condition some authors consider the most common type of hydrocephalus in adults. This disorder characteristically affects the elderly population, and clinical manifestations include progressive gait impairment, cognitive deficits, and urinary problems. The estimated incidence of NPH is 0.2–5.5 per 100 000 person-years, and reports of its prevalence increase with age and are almost three percent for persons aged 65 or older. The pathophysiological mechanism of NPH is not well known, and many hypotheses are in the literature to explain it. Some of these are reduced compliance of the subarachnoid space, leading to a stiff brain, reduced reabsorption of CSF, decreased cerebral blood flow, and an increased concentration of toxic metabolites in brain interstitial fluid.
Keywords: cerebrospinal fluid flowmetry, magnetic resonance imaging, normal pressure hydrocephalus
Full text available at:
DOI
10.4103/mmj.mmj_295_21
Citation
Rissardo JP, Caprara AL. Comprehensive idiopathic normal-pressure hydrocephalus theory: pathophysiological mechanism. Menoufia Med J 2022;35:2091-2
